Version 5.4
Mus musculus Protein: Mettl8
Summary
InnateDB Protein IDBP-256539.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mettl8
Protein Name methyltransferase like 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107804
InnateDB Gene IDBG-178244 (Mettl8)
Protein Structure
UniProt Annotation
Function Probable methyltransferase (By similarity). Isoform 5 overexpression in lung progenitor cells stimulates smooth muscle- specific gene expression and suppresses adipogenic gene expression. Isoform 4 and isoform 7 stimulate adipogenesis. {ECO:0000250, ECO:0000269PubMed:15992539, ECO:0000269PubMed:18710950}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15992539}. Nucleus {ECO:0000269PubMed:15992539}. Note=Isoform 5 localizes to the nucleus upon cell stretch in embryonic lung progenitor cells.
Disease Associations
Tissue Specificity Isoform 5 is absent in undifferentiated embryonic lung mesenchymal cells, but expression is induced by stretch. Isoform 4 is expressed in undifferentiated progenitor cells, while its expression is inhibited by stretch. Isoform 2 is absent in embryonic lung but is induced in a fibroblast cell line by stretch. Isoform 7 is expressed in mature adipose tissue. {ECO:0000269PubMed:15992539}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0016573 histone acetylation
GO:0032259 methylation
GO:0045444 fat cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2385142
InterPro IPR004033 UbiE/COQ5 methyltransferase
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR026113 Methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01209
PF08241
PF08242
PRINTS
PIRSF PIRSF037755
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AUU0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 228019
UniGene Mm.490343
RefSeq NP_663499
MGI ID
MGI Symbol Mettl8
OMIM
CCDS CCDS50600
HPRD
IMGT
EMBL AL929228 BC004636 BC057960 DQ093357 DQ093358 DQ230973 DQ230974
GenPept AAH04636 AAH57960 AAZ04166 AAZ04167 ABB54392 ABB54393 CAM22148 CAM22151

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca