Version 5.4
Mus musculus Gene: Mettl8
Summary
InnateDB Gene IDBG-178244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mettl8
Gene Name methyltransferase like 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041975
Encoded Proteins
IDBP-178248
methyltransferase like 8
IDBP-178250
methyltransferase like 8
IDBP-256539
methyltransferase like 8
IDBP-256541
methyltransferase like 8
IDBP-400292
methyltransferase like 8
IDBP-536238
methyltransferase like 8
IDBP-534134
methyltransferase like 8
IDBP-540921
methyltransferase like 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70964561-71055583
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000100037 ENSMUSP00000097615
ENSMUST00000090849 ENSMUSP00000088359
ENSMUST00000112186 ENSMUSP00000107804
ENSMUST00000112179 ENSMUSP00000107800
ENSMUST00000121586 ENSMUSP00000113642
ENSMUST00000148876 ENSMUSP00000115855
ENSMUST00000140293 ENSMUSP00000118026
ENSMUST00000149181 ENSMUSP00000119863
ENSMUST00000124781
ENSMUST00000124208
ENSMUST00000124273
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0016573 histone acetylation
GO:0032259 methylation
GO:0045444 fat cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123600
View Gene Order
ENSBTAG00000016430
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.282641 Mm.483553 Mm.490343
RefSeq NM_001110512 NM_145524
OMIM
CCDS CCDS50600
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca