InnateDB Protein
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IDBP-256541.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mettl8
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Protein Name
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methyltransferase like 8
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000107800
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InnateDB Gene
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IDBG-178244 (Mettl8)
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Protein Structure
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Function |
Probable methyltransferase (By similarity). Isoform 5 overexpression in lung progenitor cells stimulates smooth muscle- specific gene expression and suppresses adipogenic gene expression. Isoform 4 and isoform 7 stimulate adipogenesis. {ECO:0000250, ECO:0000269PubMed:15992539, ECO:0000269PubMed:18710950}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15992539}. Nucleus {ECO:0000269PubMed:15992539}. Note=Isoform 5 localizes to the nucleus upon cell stretch in embryonic lung progenitor cells.
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Disease Associations |
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Tissue Specificity |
Isoform 5 is absent in undifferentiated embryonic lung mesenchymal cells, but expression is induced by stretch. Isoform 4 is expressed in undifferentiated progenitor cells, while its expression is inhibited by stretch. Isoform 2 is absent in embryonic lung but is induced in a fibroblast cell line by stretch. Isoform 7 is expressed in mature adipose tissue. {ECO:0000269PubMed:15992539}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004402
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histone acetyltransferase activity
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GO:0008168
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methyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2385142
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InterPro |
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A2AUU0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
228019
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UniGene |
Mm.490343
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RefSeq |
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MGI ID |
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MGI Symbol |
Mettl8
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AL929228
BC004636
BC057960
DQ093357
DQ093358
DQ230973
DQ230974
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GenPept |
AAH04636
AAH57960
AAZ04166
AAZ04167
ABB54392
ABB54393
CAM22148
CAM22151
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