InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amelx

Summary

InnateDB Protein

IDBP-256670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amelx

Protein Name

amelogenin X chromosome

Synonyms

ALGN; Amel; Amg; AMGL; AMGX; LRAP; M100888; Rgsc888;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107748

InnateDB Gene

IDBG-185836 (Amelx)

Protein Structure

UniProt Annotation

Function

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042802	identical protein binding
GO:0046848	hydroxyapatite binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0034505	tooth mineralization
GO:0042475	odontogenesis of dentin-containing tooth