InnateDB Protein
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IDBP-256750.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dynll1
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Protein Name
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dynein light chain LC8-type 1
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Synonyms
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Dlc8; Dnclc1; Pin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000107720
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InnateDB Gene
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IDBG-193625 (Dynll1)
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Protein Structure
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Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). {ECO:0000250}.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. {ECO:0000250}.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. {ECO:0000250}.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated |
Total |
87
[view]
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Protein-Protein |
87
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
68 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1861457
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InterPro |
IPR001372
Dynein light chain, type 1/2
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PFAM |
PF01221
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63168
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PhosphoSite |
PhosphoSite-P63168
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56455
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UniGene |
Mm.256858
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RefSeq |
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MGI ID |
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MGI Symbol |
Dynll1
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OMIM |
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CCDS |
CCDS39227
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HPRD |
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IMGT |
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EMBL |
AF020185
AK002522
AK010614
AK010685
AK013721
AK082923
AK147977
BC008106
BC034258
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GenPept |
AAD01643
AAH08106
AAH34258
BAB22160
BAB27063
BAB27117
BAB28970
BAC38691
BAE28262
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