Version 5.4
Mus musculus Gene: Dynll1
Summary
InnateDB Gene IDBG-193625.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dynll1
Gene Name dynein light chain LC8-type 1
Synonyms Dlc8; Dnclc1; Pin
Species Mus musculus
Ensembl Gene ENSMUSG00000009013
Encoded Proteins
IDBP-193627
dynein light chain LC8-type 1
IDBP-256750
dynein light chain LC8-type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088986:
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:115297110-115300999
Strand Reverse strand
Band F
Transcripts
ENSMUST00000009157 ENSMUSP00000009157
ENSMUST00000112090 ENSMUSP00000107720
ENSMUST00000123292
ENSMUST00000127552
ENSMUST00000125959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 87 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0006915 apoptotic process
GO:0007017 microtubule-based process
GO:0007018 microtubule-based movement
GO:0021762 substantia nigra development
GO:0042326 negative regulation of phosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000088986
View Gene Order
ENSBTAG00000024605
Not yet available
Pathways
NETPATH
REACTOME
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_258521
Apoptosis pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_188804
Cell Cycle pathway
REACT_230745
Immune System pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_229531
Adaptive Immune System pathway
REACT_259244
Activation of BIM and translocation to mitochondria pathway
REACT_253753
Centrosome maturation pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_1650
Activation of BIM and translocation to mitochondria pathway
REACT_578
Apoptosis pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_223914
G2/M Transition pathway
REACT_206047
Activation of BIM and translocation to mitochondria pathway
REACT_219199
Activation of BH3-only proteins pathway
REACT_213138
Immune System pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_205006
Loss of Nlp from mitotic centrosomes pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_214934
Cell Cycle pathway
REACT_214350
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_222195
Intrinsic Pathway for Apoptosis pathway
REACT_214469
Adaptive Immune System pathway
REACT_224118
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_215812
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_210400
Centrosome maturation pathway
REACT_219454
Apoptosis pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.256858
RefSeq NM_019682
OMIM
CCDS CCDS39227
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca