InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clec7a

Summary

InnateDB Protein

IDBP-256774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clec7a

Protein Name

C-type lectin domain family 7, member a

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107707

InnateDB Gene

IDBG-256772 (Clec7a)

Protein Structure

UniProt Annotation

Function

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. {ECO:0000269PubMed:10779524, ECO:0000269PubMed:11544516, ECO:0000269PubMed:12719479, ECO:0000269PubMed:15213161, ECO:0000269PubMed:15729357, ECO:0000269PubMed:15731053, ECO:0000269PubMed:15845454, ECO:0000269PubMed:16825490}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10779524, ECO:0000269PubMed:15213161}; Single-pass type II membrane protein {ECO:0000269PubMed:10779524, ECO:0000269PubMed:15213161}. Note=Enriched on zymosan phagosomes. Enrichment does not depend on opsonization.

Disease Associations

Tissue Specificity

Detected in spleen (at protein level). Highly expressed in dendritic cells, spleen and thymus. Detected in epidermal Langerhans cells. Detected in macrophages, liver and lung. {ECO:0000269PubMed:10779524, ECO:0000269PubMed:11544516, ECO:0000269PubMed:12719479}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0001872	(1->3)-beta-D-glucan binding
GO:0001874	(1->3)-beta-D-glucan receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding

Biological Process

GO:0001878	response to yeast
GO:0001879	detection of yeast
GO:0002238	response to molecule of fungal origin
GO:0002366	leukocyte activation involved in immune response
GO:0002752	cell surface pattern recognition receptor signaling pathway
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0006954	inflammatory response
GO:0016337	single organismal cell-cell adhesion
GO:0032760	positive regulation of tumor necrosis factor production
GO:0045087	innate immune response (InnateDB)
GO:0050766	positive regulation of phagocytosis
GO:0071226	cellular response to molecule of fungal origin

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1861431

InterPro

IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold

PFAM

PF00059

PRINTS

PR00356

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6QLQ4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.239516

RefSeq

MGI ID

2CL8

MGI Symbol

Clec7a

OMIM

CCDS

HPRD

IMGT

EMBL

AC138620 AF262985 AY534909 BC027742

GenPept

AAF72710 AAH27742 AAS37670