InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clec7a

Summary

InnateDB Gene

IDBG-256772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clec7a

Gene Name

C-type lectin domain family 7, member a

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079293

Encoded Proteins

IDBP-256774

C-type lectin domain family 7, member a

IDBP-789651

C-type lectin domain family 7, member a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21267996

Clec7a, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec7a is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.

PMID 21677049

Clec7a is expressed mainly in DCs and macrophages. Clec7a recognizes beta-glucans with its carbohydrate recognition domain and transduces signals through its ITAM-like motif in the cytoplasmic region, which recruits Syk and initiates the Card9/NFkB signalling cascade.

PMID 22267217

Clec7a acts as an extracellular sensor for fungi and mycobacteria that induce both Il1b production and maturation for protective immunity. (Demonstrated in human)

PMID 22543832

The functional activity of Clec7a in mucosal immunity to Candida albicans is dependent on the genetic background of the host; this was specifically observed in two strains of mice, C57BL/6 and BALB/c.

PMID 23386437

Clec7a is necessary for macrophage activation and resistance to pathogenic fungus Coccidioidesimmitis.

PMID 25538234

Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.

InnateDB Annotation from Orthologs

Summary

PMID 15956283

[Homo sapiens] CLEC7A (Dectin-1) is a C-type lectin receptor that binds beta-glucan and is the primary receptor on macrophages for phagocytosis of various fungi.

PMID 17698636

[Homo sapiens] CLEC7A synergizes with TLR2 to increase pro-inflammatory cytokine responses to pathogens.

PMID 19633936

[Homo sapiens] CLEC7A has a critical role in the innate immune response against Mycobacterium tuberculosis in non-phagocytic cells in type II airway epithelial cells.

PMID 20100861

[Homo sapiens] CLEC7A-dependent immune-cell recognition of beta glucan on the fungal cell-wall is modulated by the Candida albicans ERK-like-1 (CEK1)-mediated MAPK pathway, disruption of which causes enhanced cell-wall beta-glucan exposure triggering immune responses more efficiently than wild-type yeast.

PMID 21267996

[Homo sapiens] CLEC7A, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC7A is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.

PMID 21677049

[Homo sapiens] CLEC7A is expressed mainly in dendritic cells and macrophages. CLEC7A recognizes beta-glucans with its carbohydrate recognition domain and transduces signals through its ITAM-like motif in the cytoplasmic region, which recruits SYK and initiates the CARD9/NFkB signalling cascade.

PMID 22267217

[Homo sapiens] CLEC7A acts as an extracellular sensor for fungi and mycobacteria that induce both IL1B production and maturation for protective immunity.

PMID 22543832

[Homo sapiens] The functional activity of CLEC7A in mucosal immunity to Candida albicans is dependent on the genetic background of the host. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172243:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:129461591-129472777

Strand

Reverse strand

Band

Transcripts

ENSMUST00000112076	ENSMUSP00000107707
ENSMUST00000184581	ENSMUSP00000139167

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0001872	(1->3)-beta-D-glucan binding
GO:0001874	(1->3)-beta-D-glucan receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding

Biological Process

GO:0001878	response to yeast
GO:0001879	detection of yeast
GO:0002238	response to molecule of fungal origin
GO:0002366	leukocyte activation involved in immune response
GO:0002752	cell surface pattern recognition receptor signaling pathway
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0006954	inflammatory response
GO:0016337	single organismal cell-cell adhesion
GO:0032760	positive regulation of tumor necrosis factor production
GO:0045087	innate immune response (InnateDB)
GO:0050766	positive regulation of phagocytosis
GO:0071226	cellular response to molecule of fungal origin

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000172243

View Gene Order

ENSBTAG00000014546

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q6QLQ4

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.239516

RefSeq

OMIM

CCDS

HPRD

IMGT

MGI ID

MGI:1861431

MGI Symbol

Clec7a

EMBL

AC138620 AF262985 AY534909 BC027742

GenPept

AAF72710 AAH27742 AAS37670

RNA Seq Atlas