InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chn1

Summary

InnateDB Protein

IDBP-256865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chn1

Protein Name

chimerin (chimaerin) 1

Synonyms

0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik; AI413815; ARHGAP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107655

InnateDB Gene

IDBG-180318 (Chn1)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal- transduction mechanisms (By similarity). Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. {ECO:0000250, ECO:0000269PubMed:17785183}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0007165	signal transduction
GO:0008045	motor neuron axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0048013	ephrin receptor signaling pathway
GO:0050770	regulation of axonogenesis

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:1915674

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR008936 Rho GTPase activation protein
IPR017356 N-chimaerin
IPR020454 Diacylglycerol/phorbol-ester binding

PFAM

PF00620
PF00017
PF14633
PF00130

PRINTS

PR00401
PR00008

PIRSF

PIRSF038015

SMART

SM00324
SM00252
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References