Version 5.4
Mus musculus Gene: Chn1
Summary
InnateDB Gene IDBG-180318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chn1
Gene Name chimerin (chimaerin) 1
Synonyms 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik; AI413815; ARHGAP2
Species Mus musculus
Ensembl Gene ENSMUSG00000056486
Encoded Proteins
IDBP-180320
chimerin (chimaerin) 1
IDBP-180322
chimerin (chimaerin) 1
IDBP-256865
chimerin (chimaerin) 1
IDBP-542085
chimerin (chimaerin) 1
IDBP-541612
chimerin (chimaerin) 1
IDBP-538716
chimerin (chimaerin) 1
IDBP-542601
chimerin (chimaerin) 1
IDBP-533507
chimerin (chimaerin) 1
IDBP-622886
chimerin (chimaerin) 1
IDBP-719237
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128656:
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane\'s retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73610660-73775346
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000102677 ENSMUSP00000099738
ENSMUST00000070579 ENSMUSP00000070301
ENSMUST00000112024 ENSMUSP00000107655
ENSMUST00000124450 ENSMUSP00000116708
ENSMUST00000154258 ENSMUSP00000116417
ENSMUST00000136953 ENSMUSP00000123551
ENSMUST00000139252 ENSMUSP00000123312
ENSMUST00000135904 ENSMUSP00000115029
ENSMUST00000166199 ENSMUSP00000128847
ENSMUST00000180045 ENSMUSP00000137106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007165 signal transduction
GO:0008045 motor neuron axon guidance
GO:0032314 regulation of Rac GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128656
View Gene Order
ENSBTAG00000008028
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL A7VK14
UniProt Splice Variant
Entrez Gene 108699
UniGene Mm.475577 Mm.489675
RefSeq NM_029716 NM_001113246 NM_001166603 NM_001166604 NM_175752
OMIM
CCDS CCDS38145 CCDS16133 CCDS50607 CCDS50608
HPRD
IMGT
MGI ID MGI:1915674
MGI Symbol Chn1
EMBL AB264774
GenPept BAF80063
RNA Seq Atlas 108699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca