InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgap22

Summary

InnateDB Protein

IDBP-257023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap22

Protein Name

Rho GTPase activating protein 22

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107587

InnateDB Gene

IDBG-148277 (Arhgap22)

Protein Structure

UniProt Annotation

Function

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. {ECO:0000269PubMed:14966113}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14966113}. Nucleus {ECO:0000269PubMed:14966113}. Note=Mainly cytoplasmic. Some fraction is nuclear.

Disease Associations

Tissue Specificity

Predominantly present in endothelial cells (at protein level). {ECO:0000269PubMed:14966113}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0030154	cell differentiation
GO:0043547	positive regulation of GTPase activity