Version 5.4
Mus musculus Gene: Arhgap22
Summary
InnateDB Gene IDBG-148277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap22
Gene Name Rho GTPase activating protein 22
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000063506
Encoded Proteins
IDBP-257023
Rho GTPase activating protein 22
IDBP-257025
Rho GTPase activating protein 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128805:
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:33214026-33369934
Strand Forward strand
Band B
Transcripts
ENSMUST00000111956 ENSMUSP00000107587
ENSMUST00000111955 ENSMUSP00000107586
ENSMUST00000131086
ENSMUST00000137590
ENSMUST00000140711
ENSMUST00000140166
ENSMUST00000132659
ENSMUST00000165792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0030154 cell differentiation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128805
View Gene Order
ENSBTAG00000007878
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.318350 Mm.481212
RefSeq NM_153800 XM_006518955 XM_006518962
OMIM
CCDS CCDS26926
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca