Version 5.4
Mus musculus Protein: Mapk8
Summary
InnateDB Protein IDBP-257045.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Mapk8
Protein Name mitogen-activated protein kinase 8
Synonyms AI849689; JNK; JNK1; Prkm8; SAPK1;
Species Mus musculus
Ensembl Protein ENSMUSP00000107573
InnateDB Gene IDBG-148417 (Mapk8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 139 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 139 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004705 JUN kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001503 ossification
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010468 regulation of gene expression
GO:0018107 peptidyl-threonine phosphorylation
GO:0046686 response to cadmium ion
GO:0048263 determination of dorsal identity
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071732 cellular response to nitric oxide
GO:0097300 programmed necrotic cell death
GO:2000017 positive regulation of determination of dorsal identity
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1346861
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR008351 Mitogen-activated protein (MAP) kinase, JNK
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF06293
PRINTS PR00109
PR01772
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z1Z4
UniProt Splice Variant
Entrez Gene 26419
UniGene Mm.412411
RefSeq
MGI ID
MGI Symbol Mapk8
OMIM
CCDS
HPRD
IMGT
EMBL AC154649
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca