InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mapk8

Summary

InnateDB Gene

IDBG-148417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk8

Gene Name

mitogen-activated protein kinase 8

Synonyms

AI849689; JNK; JNK1; Prkm8; SAPK1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021936

Encoded Proteins

IDBP-148419

mitogen-activated protein kinase 8

IDBP-257039

mitogen-activated protein kinase 8

IDBP-257041

mitogen-activated protein kinase 8

IDBP-257043

mitogen-activated protein kinase 8

IDBP-257045

mitogen-activated protein kinase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24185614

Phosphorylation of the inflammasome adaptor Pycard (ASC) controls inflammasome activity through the formation of ASC specks. The NLRP3 and AIM2 inflammasomes require Syk and Mapk8 (JNK) for their full activity .

InnateDB Annotation from Orthologs

Summary

PMID 19153595

[Homo sapiens] MAPK8 phosphorylates IRF3 and is essential for IRF3 dimerization induced by polyinosinic-cytidylic acid (polyI:C).

PMID 25642820

[Homo sapiens] Mycobacterium tuberculosis phosphatase PtpA suppresses innate immunity by binding to ubiquitin; which, in turn, activates it to dephosphorylate phosphorylated MAPK8 and MAPK14.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107643:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:33377898-33447158

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022504	ENSMUSP00000022504
ENSMUST00000111945	ENSMUSP00000107576
ENSMUST00000111944	ENSMUSP00000107575
ENSMUST00000111943	ENSMUSP00000107574
ENSMUST00000111942	ENSMUSP00000107573
ENSMUST00000150659
ENSMUST00000127143
ENSMUST00000130539
ENSMUST00000132379

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 139 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	139 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004705	JUN kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035033	histone deacetylase regulator activity
GO:0042826	histone deacetylase binding

Biological Process

GO:0001503	ossification
GO:0006468	protein phosphorylation
GO:0007254	JNK cascade
GO:0007258	JUN phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009411	response to UV
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0031063	regulation of histone deacetylation
GO:0032091	negative regulation of protein binding
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046686	response to cadmium ion
GO:0048263	determination of dorsal identity
GO:0070301	cellular response to hydrogen peroxide
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0071732	cellular response to nitric oxide
GO:0090045	positive regulation of deacetylase activity
GO:0097300	programmed necrotic cell death
GO:2000017	positive regulation of determination of dorsal identity
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000107643

View Gene Order

Pathways

NETPATH

REACTOME

REACT_263316

Toll Like Receptor 3 (TLR3) Cascade pathway

REACT_229712

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway

REACT_263004

Toll Like Receptor 2 (TLR2) Cascade pathway

REACT_239142

Innate Immune System pathway

REACT_258521

Apoptosis pathway

REACT_188970

Oxidative Stress Induced Senescence pathway

REACT_204811

Activation of the AP-1 family of transcription factors pathway

REACT_210065

MAPK targets/ Nuclear events mediated by MAP kinases pathway

REACT_188957

Cellular responses to stress pathway

REACT_204812

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway

REACT_245896

MyD88 cascade initiated on plasma membrane pathway

REACT_209641

NRAGE signals death through JNK pathway

REACT_255939

Toll Like Receptor TLR1:TLR2 Cascade pathway

REACT_262171

MAP kinase activation in TLR cascade pathway

REACT_230745

Immune System pathway

REACT_260773

Toll Like Receptor 5 (TLR5) Cascade pathway

REACT_254406

Toll Like Receptor TLR6:TLR2 Cascade pathway

REACT_243212

DSCAM interactions pathway

REACT_188820

Cellular Senescence pathway

REACT_249409

Toll Like Receptor 9 (TLR9) Cascade pathway

REACT_204413

Cell death signalling via NRAGE, NRIF and NADE pathway

REACT_188204

Fc epsilon receptor (FCERI) signaling pathway

REACT_251547

Toll-Like Receptors Cascades pathway

REACT_256727

MyD88 dependent cascade initiated on endosome pathway

REACT_248921

Signalling by NGF pathway

REACT_212161

Activation of BH3-only proteins pathway

REACT_262462

Activated TLR4 signalling pathway

REACT_229508

Activation of BMF and translocation to mitochondria pathway

REACT_241786

MyD88-independent cascade pathway

REACT_259244

Activation of BIM and translocation to mitochondria pathway

REACT_188257

Signal Transduction pathway

REACT_210847

p75 NTR receptor-mediated signalling pathway

REACT_242921

Toll Like Receptor 7/8 (TLR7/8) Cascade pathway

REACT_202271

NRIF signals cell death from the nucleus pathway

REACT_230045

MyD88:Mal cascade initiated on plasma membrane pathway

REACT_238546

TRIF-mediated TLR3/TLR4 signaling pathway

REACT_188530

FCERI mediated MAPK activation pathway

REACT_223082

Cell-Cell communication pathway

REACT_261340

Toll Like Receptor 10 (TLR10) Cascade pathway

REACT_246719

Toll Like Receptor 4 (TLR4) Cascade pathway

REACT_204001

Intrinsic Pathway for Apoptosis pathway

KEGG

mmu04012

ErbB signaling pathway pathway

mmu04930

Type II diabetes mellitus pathway

mmu04910

Insulin signaling pathway pathway

mmu04310

Wnt signaling pathway pathway

mmu04620

Toll-like receptor signaling pathway pathway

mmu05210

Colorectal cancer pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu04912

GnRH signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

mmu04920

Adipocytokine signaling pathway pathway

mmu04510

Focal adhesion pathway

mmu05212

Pancreatic cancer pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu05200

Pathways in cancer pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu04622

RIG-I-like receptor signaling pathway pathway

mmu04621

NOD-like receptor signaling pathway pathway

mmu04380

Osteoclast differentiation pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

mmu05145

Toxoplasmosis pathway

mmu05160

Hepatitis C pathway

mmu05142

Chagas disease (American trypanosomiasis) pathway

INOH