Version 5.4
Mus musculus Protein: Fgf8
Summary
InnateDB Protein IDBP-257091.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Fgf8
Protein Name fibroblast growth factor 8
Synonyms Aigf; Fgf-8;
Species Mus musculus
Ensembl Protein ENSMUSP00000107555
InnateDB Gene IDBG-171054 (Fgf8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000165 MAPK cascade
GO:0001569 patterning of blood vessels
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001839 neural plate morphogenesis
GO:0001947 heart looping
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0008045 motor neuron axon guidance
GO:0008078 mesodermal cell migration
GO:0008284 positive regulation of cell proliferation
GO:0008406 gonad development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009792 embryo development ending in birth or egg hatching
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021846 cell proliferation in forebrain
GO:0021884 forebrain neuron development
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030324 lung development
GO:0030509 BMP signaling pathway
GO:0030539 male genitalia development
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030917 midbrain-hindbrain boundary development
GO:0033563 dorsal/ventral axon guidance
GO:0035050 embryonic heart tube development
GO:0035108 limb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035909 aorta morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045840 positive regulation of mitosis
GO:0046622 positive regulation of organ growth
GO:0048699 generation of neurons
GO:0048853 forebrain morphogenesis
GO:0050918 positive chemotaxis
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060037 pharyngeal system development
GO:0060070 canonical Wnt signaling pathway
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060348 bone development
GO:0060425 lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0071542 dopaminergic neuron differentiation
GO:0090134 cell migration involved in mesendoderm migration
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:99604
InterPro IPR002209 Fibroblast growth factor family
IPR008996 Cytokine, IL-1-like
IPR028142 IL-1 family/FGF family
PFAM
PRINTS PR00263
PR00262
PIRSF
SMART SM00442
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z208
UniProt Splice Variant
Entrez Gene 14179
UniGene Mm.4012
RefSeq
MGI ID
MGI Symbol Fgf8
OMIM
CCDS
HPRD
IMGT
EMBL AC149086
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca