InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELP2

Summary

InnateDB Protein

IDBP-2571.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELP2

Protein Name

elongation protein 2 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000316051

InnateDB Gene

IDBG-2565 (ELP2)

Protein Structure

UniProt Annotation

Function

Regulates the ligand-dependent activation of STAT3. {ECO:0000250}.Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. {ECO:0000269PubMed:11714725, ECO:0000269PubMed:11818576}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006325	chromatin organization
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0008023	transcription elongation factor complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0033588	Elongator holoenzyme complex