Version 5.4
Homo sapiens Gene: ELP2
Summary
InnateDB Gene IDBG-2565.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELP2
Gene Name elongator acetyltransferase complex subunit 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134759
Encoded Proteins
IDBP-2567
elongation protein 2 homolog (S. cerevisiae)
IDBP-2569
elongation protein 2 homolog (S. cerevisiae)
IDBP-2571
elongation protein 2 homolog (S. cerevisiae)
IDBP-367923
elongation protein 2 homolog (S. cerevisiae)
IDBP-367939
elongation protein 2 homolog (S. cerevisiae)
IDBP-594890
elongation protein 2 homolog (S. cerevisiae)
IDBP-602422
elongation protein 2 homolog (S. cerevisiae)
IDBP-597223
elongation protein 2 homolog (S. cerevisiae)
IDBP-594694
elongation protein 2 homolog (S. cerevisiae)
IDBP-599395
elongation protein 2 homolog (S. cerevisiae)
IDBP-585963
elongation protein 2 homolog (S. cerevisiae)
IDBP-727699
IDBP-596122
elongation protein 2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 10954736
ELP2 is a STAT3-interacting protein that regulates cytokine signal transduction and may regulate the activation of STAT3.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:36129444-36180556
Strand Forward strand
Band q12.2
Transcripts
ENST00000358232 ENSP00000350967
ENST00000351393 ENSP00000257191
ENST00000350494 ENSP00000316051
ENST00000423854 ENSP00000391202
ENST00000442325 ENSP00000414851
ENST00000543127 ENSP00000440426
ENST00000544267 ENSP00000440516
ENST00000541190
ENST00000545632 ENSP00000438533
ENST00000539560 ENSP00000443555
ENST00000535488
ENST00000540135
ENST00000542430 ENSP00000440774
ENST00000542824 ENSP00000443800
ENST00000540799 ENSP00000468091
ENST00000543439
ENST00000540730
ENST00000540323
ENST00000536373
ENST00000535093
ENST00000542050
ENST00000543861
ENST00000540766 ENSP00000440651
ENST00000541294
ENST00000545302
ENST00000541748
ENST00000536830
ENST00000544274
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006325 chromatin organization
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0045087 innate immune response (InnateDB)
GO:0046425 regulation of JAK-STAT cascade
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0008023 transcription elongation factor complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0033588 Elongator holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024271
View Gene Order
ENSBTAG00000018954
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596083 Hs.606040 Hs.668694 Hs.8739
RefSeq NM_001242875 NM_001242876 NM_001242877 NM_001242878 NM_001242879 NM_018255
HUGO
OMIM
CCDS CCDS11918 CCDS56065 CCDS56066 CCDS56067 CCDS56068 CCDS56069
HPRD 15443
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca