Version 5.4
Mus musculus Protein: Rgs8
Summary
InnateDB Protein IDBP-257326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs8
Protein Name regulator of G-protein signaling 8
Synonyms 6530413N01Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000107443
InnateDB Gene IDBG-199207 (Rgs8)
Protein Structure
UniProt Annotation
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:108408
InterPro IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00615
PRINTS PR01301
PIRSF
SMART SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BXT1
PhosphoSite PhosphoSite-Q8BXT1
TrEMBL D3Z5I4
UniProt Splice Variant
Entrez Gene 67792
UniGene Mm.401790
RefSeq
MGI ID
MGI Symbol Rgs8
OMIM
CCDS CCDS15375
HPRD
IMGT
EMBL AC154140 AK044337 AK142301 BC065056 BC094577
GenPept AAH65056 AAH94577 BAC31874 BAE25020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca