InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cux2

Summary

InnateDB Protein

IDBP-257455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cux2

Protein Name

cut-like homeobox 2

Synonyms

1700051K22Rik; Cutl2; Cux-2; ENSMUSG00000072641;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107381

InnateDB Gene

IDBG-197822 (Cux2)

Protein Structure

UniProt Annotation

Function

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007614	short-term memory
GO:0010628	positive regulation of gene expression
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050775	positive regulation of dendrite morphogenesis
GO:0050890	cognition
GO:0051965	positive regulation of synapse assembly
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0071310	cellular response to organic substance
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:107321

InterPro

IPR001356 Homeobox domain
IPR003350 Homeodomain protein CUT
IPR009053 Prefoldin
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain

PFAM

PF00046
PF02376
PF13413

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70298