InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox5

Summary

InnateDB Protein

IDBP-257461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox5

Protein Name

SRY-box containing gene 5

Synonyms

A730017D01Rik; AI528773;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107377

InnateDB Gene

IDBG-197431 (Sox5)

Protein Structure

UniProt Annotation

Function

Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. {ECO:0000269PubMed:9755172}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 is found in the embryo and in adult testis. Isoform 2 is expressed in chondrocytes and, to a lesser extent, in brain. Isoform 3 is testis-specific. {ECO:0000269PubMed:1396566, ECO:0000269PubMed:9714725, ECO:0000269PubMed:9755172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006366	transcription from RNA polymerase II promoter
GO:0021953	central nervous system neuron differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048709	oligodendrocyte differentiation
GO:0051216	cartilage development
GO:0060164	regulation of timing of neuron differentiation