Version 5.4
Mus musculus Gene: Sox5
Summary
InnateDB Gene IDBG-197431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sox5
Gene Name SRY-box containing gene 5
Synonyms A730017D01Rik; AI528773
Species Mus musculus
Ensembl Gene ENSMUSG00000041540
Encoded Proteins
IDBP-197433
SRY-box containing gene 5
IDBP-197435
SRY-box containing gene 5
IDBP-257459
SRY-box containing gene 5
IDBP-257461
SRY-box containing gene 5
IDBP-533730
SRY-box containing gene 5
IDBP-539375
SRY-box containing gene 5
IDBP-622758
SRY-box containing gene 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134532:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:143828425-144781977
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000038815 ENSMUSP00000047567
ENSMUST00000077160 ENSMUSP00000076403
ENSMUST00000111749 ENSMUSP00000107378
ENSMUST00000111748 ENSMUSP00000107377
ENSMUST00000111746
ENSMUST00000124233 ENSMUSP00000114602
ENSMUST00000141102
ENSMUST00000144289 ENSMUSP00000122786
ENSMUST00000129050
ENSMUST00000142294
ENSMUST00000149451
ENSMUST00000139478
ENSMUST00000150087
ENSMUST00000170367 ENSMUSP00000133041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006366 transcription from RNA polymerase II promoter
GO:0021953 central nervous system neuron differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048709 oligodendrocyte differentiation
GO:0051216 cartilage development
GO:0060164 regulation of timing of neuron differentiation
GO:0061036 positive regulation of cartilage development
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134532
View Gene Order
ENSBTAG00000022360
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1752
RefSeq NM_001113559 NM_001243163 NM_011444 XM_006506931 XM_006506932 XM_006506933 XM_006506934 XM_006506935 XM_006506936 XM_006506937 XM_006506938 XM_006506939 XM_006506940 XM_006506941 XM_006506942 XM_006506943 XM_006506944 XM_006506945 XM_006506946 XM_006506947 XM_006536047 XM_006536048 XM_006536049 XM_006536050 XM_006536051 XM_006536052 XM_006536053 XM_006536054 XM_006536055 XM_006536056 XM_006536057 XM_006536058 XM_006536059 XM_006536060 XM_006536061 XM_006536062 XM_006536063 XM_006536064 XM_006536065
OMIM
CCDS CCDS39702 CCDS51954 CCDS57469
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca