InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTPBP10

Summary

InnateDB Protein

IDBP-25760.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTPBP10

Protein Name

GTP-binding protein 10 (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257659

InnateDB Gene

IDBG-25756 (GTPBP10)

Protein Structure

UniProt Annotation

Function

May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed. {ECO:0000269PubMed:17054726}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:17054726}. Chromosome {ECO:0000269PubMed:17054726}. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0015684	ferrous iron transport
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005694	chromosome
GO:0005730	nucleolus
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR006073 GTP binding domain
IPR006169 GTP1/OBG domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR014100 GTP-binding protein Obg/CgtA
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF01926
PF01018
PF02421

PRINTS

PR00315
PR00326

PIRSF

PIRSF002401

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt