InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camkk2

Summary

InnateDB Protein

IDBP-257632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camkk2

Protein Name

calcium/calmodulin-dependent protein kinase kinase 2, beta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107297

InnateDB Gene

IDBG-198659 (Camkk2)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching (By similarity). May be involved in hippocampal activation of CREB1. {ECO:0000250, ECO:0000269PubMed:14586002}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Note=Predominantly nuclear in unstimulated cells. Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested. A differential expression pattern compared to CAMKK1 is observed in the brain. {ECO:0000269PubMed:12654522}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:2444812

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt