InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdrd1

Summary

InnateDB Protein

IDBP-257770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdrd1

Protein Name

tudor domain containing 1

Synonyms

MTR-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107231

InnateDB Gene

IDBG-179230 (Tdrd1)

Protein Structure

UniProt Annotation

Function

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. {ECO:0000269PubMed:17038506, ECO:0000269PubMed:19465913, ECO:0000269PubMed:19584108}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14550528, ECO:0000269PubMed:17038506, ECO:0000269PubMed:17141210, ECO:0000269PubMed:19345100, ECO:0000269PubMed:19465913, ECO:0000269PubMed:19584108}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. DDX4 is required for meiotic nuage localization. Also present in chromatoid body.

Disease Associations

Tissue Specificity

Testis and ovary specific. Present in germ- line cells and is most abundant in fetal prospermatogonia and postnatal primary spermatocytes (at protein level). {ECO:0000269PubMed:14550528}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007126	meiotic nuclear division
GO:0007275	multicellular organismal development
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0031047	gene silencing by RNA
GO:0034587	piRNA metabolic process
GO:0043046	DNA methylation involved in gamete generation