InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Diablo

Summary

InnateDB Protein

IDBP-257798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Diablo

Protein Name

diablo homolog (Drosophila)

Synonyms

0610041G12Rik; 1700006L01Rik; AU040403; Smac;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107214

InnateDB Gene

IDBG-199693 (Diablo)

Protein Structure

UniProt Annotation

Function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:10929712}. Note=Released into the cytosol when cells undergo apoptosis.

Disease Associations

Tissue Specificity

Highest expression found in heart, liver, kidney and testis. {ECO:0000269PubMed:10929712}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0043065	positive regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex