InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Diablo

Summary

InnateDB Gene

IDBG-199693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Diablo

Gene Name

diablo homolog (Drosophila)

Synonyms

0610041G12Rik; 1700006L01Rik; AU040403; Smac

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029433

Encoded Proteins

IDBP-199695

diablo homolog (Drosophila)

IDBP-257798

diablo homolog (Drosophila)

IDBP-257800

diablo homolog (Drosophila)

IDBP-531759

diablo homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184047:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:123509765-123524176

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031385	ENSMUSP00000031385
ENSMUST00000111587	ENSMUSP00000107214
ENSMUST00000111586	ENSMUSP00000107213
ENSMUST00000125652	ENSMUSP00000115045
ENSMUST00000139398
ENSMUST00000145152
ENSMUST00000125047
ENSMUST00000149334

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0043065	positive regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex