InnateDB Protein
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IDBP-258006.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Acin1
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Protein Name
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apoptotic chromatin condensation inducer 1
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Synonyms
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2610036I19Rik; 2610510L13Rik; Acinus; acinusL; acinusS; Acn; C79325; mKIAA0670;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000107109
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InnateDB Gene
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IDBG-161881 (Acin1)
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Protein Structure
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Function |
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Phosphorylation on Ser-1179 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
65 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1891824
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InterPro |
IPR003034
SAP domain
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PFAM |
PF02037
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PRINTS |
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PIRSF |
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SMART |
SM00513
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JIX8
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PhosphoSite |
PhosphoSite-Q9JIX8
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TrEMBL |
Q3UXT9
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UniProt Splice Variant |
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Entrez Gene |
56215
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UniGene |
Mm.297078
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RefSeq |
XP_006519361
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MGI ID |
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MGI Symbol |
Acin1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF124725
AF124729
AF168782
AK011698
AK012099
AK012337
AK050467
AK135284
CT009512
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GenPept |
AAD56723
AAD56727
AAF89661
BAB28030
BAB28171
BAC34272
BAE22474
CAX15406
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