Version 5.4
Mus musculus Protein: Creg1
Summary
InnateDB Protein IDBP-258122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Creg1
Protein Name cellular repressor of E1A-stimulated genes 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107060
InnateDB Gene IDBG-202763 (Creg1)
Protein Structure
UniProt Annotation
Function May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:10815803}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008134 transcription factor binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005667 transcription factor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1344382
InterPro IPR012349 FMN-binding split barrel
IPR014631 Cellular repressor of E1A-stimulated genes (CREG)
PFAM
PRINTS
PIRSF PIRSF036911
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88668
PhosphoSite PhosphoSite-O88668
TrEMBL K4DI63
UniProt Splice Variant
Entrez Gene 433375
UniGene Mm.294885
RefSeq NP_035934
MGI ID
MGI Symbol Creg1
OMIM
CCDS CCDS35759
HPRD
IMGT
EMBL AC124587 AF084524 AK005388 AK010947 AK085844 AK144101 BC027426 CH466520
GenPept AAC34862 AAH27426 BAB23994 BAB27285 BAC39549 BAE25699 EDL39216 EDL39218

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca