Version 5.4
Mus musculus Protein: Pou2f1
Summary
InnateDB Protein IDBP-258135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou2f1
Protein Name POU domain, class 2, transcription factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107055
InnateDB Gene IDBG-202815 (Pou2f1)
Protein Structure
UniProt Annotation
Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Ubiquitously expressed. However, isoforms 4 and 5 are only expressed in lymphocytes. {ECO:0000269PubMed:10023087, ECO:0000269PubMed:11683265, ECO:0000269PubMed:14729276, ECO:0000269PubMed:7711063}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0030910 olfactory placode formation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060235 lens induction in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:101898
InterPro IPR000327 POU-specific
IPR000972 Octamer-binding transcription factor
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain
PFAM PF00157
PF00046
PF13413
PRINTS PR00029
PR00028
PIRSF
SMART SM00352
SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P25425
TrEMBL H3BKX3
UniProt Splice Variant
Entrez Gene 18986
UniGene Mm.448785
RefSeq
MGI ID
MGI Symbol Pou2f1
OMIM
CCDS
HPRD
IMGT
EMBL AC093371
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca