Version 5.4
Mus musculus Gene: Pou2f1
Summary
InnateDB Gene IDBG-202815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou2f1
Gene Name POU domain, class 2, transcription factor 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026565
Encoded Proteins
IDBP-202817
POU domain, class 2, transcription factor 1
IDBP-202819
POU domain, class 2, transcription factor 1
IDBP-258131
POU domain, class 2, transcription factor 1
IDBP-258133
POU domain, class 2, transcription factor 1
IDBP-258135
POU domain, class 2, transcription factor 1
IDBP-539679
POU domain, class 2, transcription factor 1
IDBP-535816
POU domain, class 2, transcription factor 1
IDBP-539917
POU domain, class 2, transcription factor 1
IDBP-716139
IDBP-717134
IDBP-788823
POU domain, class 2, transcription factor 1
IDBP-788824
POU domain, class 2, transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143190:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:165875423-166002678
Strand Reverse strand
Band H2.3
Transcripts
ENSMUST00000027850 ENSMUSP00000027850
ENSMUST00000069609 ENSMUSP00000064000
ENSMUST00000082225
ENSMUST00000111429 ENSMUSP00000107057
ENSMUST00000111427 ENSMUSP00000107056
ENSMUST00000111426 ENSMUSP00000107055
ENSMUST00000160260 ENSMUSP00000124738
ENSMUST00000159212 ENSMUSP00000125371
ENSMUST00000160908 ENSMUSP00000125444
ENSMUST00000176942
ENSMUST00000177358 ENSMUSP00000135565
ENSMUST00000176004
ENSMUST00000176101
ENSMUST00000177472
ENSMUST00000176800 ENSMUSP00000135329
ENSMUST00000184643 ENSMUSP00000138962
ENSMUST00000184799 ENSMUSP00000139271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030910 olfactory placode formation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060235 lens induction in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143190
View Gene Order
ENSBTAG00000024534
Not yet available
Pathways
NETPATH
REACTOME
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_233104
RNA Polymerase III Transcription Initiation pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_233572
Gene Expression pathway
REACT_237241
RNA Polymerase III Transcription pathway
REACT_240508
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
atf2_pathway
ATF-2 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
ar_tf_pathway
Regulation of Androgen receptor activity
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011137 NM_198932 NM_198933 NM_198934 XM_006496704 XM_006496705 XM_006496706
OMIM
CCDS CCDS15444 CCDS35760 CCDS48430 CCDS35761
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca