InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Madd

Summary

InnateDB Protein

IDBP-258155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Madd

Protein Name

MAP-kinase activating death domain

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107001

InnateDB Gene

IDBG-190319 (Madd)

Protein Structure

UniProt Annotation

Function

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis). {ECO:0000269PubMed:14735464, ECO:0000269PubMed:15007167}.

Subcellular Localization

Membrane {ECO:0000250UniProtKB:Q8WXG6}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017112	Rab guanyl-nucleotide exchange factor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0032313	regulation of Rab GTPase activity
GO:0051726	regulation of cell cycle
GO:0097194	execution phase of apoptosis
GO:2001234	negative regulation of apoptotic signaling pathway