InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncor2

Summary

InnateDB Protein

IDBP-258196.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncor2

Protein Name

nuclear receptor co-repressor 2

Synonyms

N-CoR; SMRT; SMRTe;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107029

InnateDB Gene

IDBG-201131 (Ncor2)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269PubMed:19144721}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. Also widely expressed in early embryos.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	17 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0021537	telencephalon development
GO:0021846	cell proliferation in forebrain
GO:0030900	forebrain development
GO:0042593	glucose homeostasis
GO:0045599	negative regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0060509	Type I pneumocyte differentiation

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005654	nucleoplasm
GO:0016363	nuclear matrix
GO:0016604	nuclear body

Protein Structure and Domains

PDB ID

MGI:1337080

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain

PFAM

PF00249

PRINTS

PIRSF

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WU42

PhosphoSite

PhosphoSite-Q9WU42

TrEMBL

Q3TG88

UniProt Splice Variant

Entrez Gene

20602

UniGene

Mm.472258

RefSeq

MGI ID

MGI Symbol

Ncor2

OMIM

CCDS

HPRD

IMGT

EMBL

AC132118 AC139377 AF113001 AF113002 AF125671 AK168836

GenPept

AAD20944 AAD20945 AAD22972 BAE40660