Mus musculus Gene: Ncor2 | |||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-201131.6 | ||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
Gene Symbol | Ncor2 | ||||||||||||||||||||||||||||||||||||
Gene Name | nuclear receptor co-repressor 2 | ||||||||||||||||||||||||||||||||||||
Synonyms | N-CoR; SMRT; SMRTe | ||||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029478 | ||||||||||||||||||||||||||||||||||||
Encoded Proteins |
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
nuclear receptor co-repressor 2
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Protein Structure | |||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196498:
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011] |
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Gene Information | |||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 5:125017153-125179219 | ||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
Band | G1.1 | ||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||
REACTOME |
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Transcriptional regulation of white adipocyte differentiation pathway
Mus musculus biological processes pathway
Chromatin organization pathway
Disease pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Loss of Function of TGFBR2 in Cancer pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Developmental Biology pathway
Loss of Function of TGFBR1 in Cancer pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
HDACs deacetylate histones pathway
Signaling by NOTCH pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
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KEGG |
Notch signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
Notch pathway
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REACTOME |
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Generic Transcription Pathway pathway
Transcriptional regulation of white adipocyte differentiation pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Developmental Biology pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
HDACs deacetylate histones pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
TGFBR1 KD Mutants in Cancer pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Metabolism pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
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KEGG |
Notch signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||||
PID NCI |
RXR and RAR heterodimerization with other nuclear receptor
Validated nuclear estrogen receptor alpha network
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Retinoic acid receptors-mediated signaling
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Cross-References | |||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||
UniGene | Mm.278646 Mm.472258 | ||||||||||||||||||||||||||||||||||||
RefSeq | NM_001253904 NM_001253905 NM_011424 XM_006504281 XM_006504282 XM_006504283 | ||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||
CCDS | CCDS39285 CCDS57381 CCDS57382 | ||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||