InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncor2

Summary

InnateDB Protein

IDBP-258198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncor2

Protein Name

nuclear receptor co-repressor 2

Synonyms

N-CoR; SMRT; SMRTe;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107025

InnateDB Gene

IDBG-201131 (Ncor2)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269PubMed:19144721}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. Also widely expressed in early embryos.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	17 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0021537	telencephalon development
GO:0021846	cell proliferation in forebrain
GO:0030900	forebrain development
GO:0042593	glucose homeostasis
GO:0045599	negative regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0060509	Type I pneumocyte differentiation