InnateDB Protein
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IDBP-258282.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nuf2
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Protein Name
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NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
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Synonyms
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2410003C07Rik; AU044112; C85691; Cdca1; NUF2R;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106999
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InnateDB Gene
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IDBG-203463 (Nuf2)
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Protein Structure
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Function |
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
22 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914227
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InterPro |
IPR005549
Kinetochore protein Nuf2
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PFAM |
PF03800
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99P69
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PhosphoSite |
PhosphoSite-Q99P69
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66977
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UniGene |
Mm.350612
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RefSeq |
NP_075773
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MGI ID |
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MGI Symbol |
Nuf2
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OMIM |
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CCDS |
CCDS15463
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HPRD |
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IMGT |
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EMBL |
AF326732
AK012011
AK089939
AK132467
AK162249
BC020026
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GenPept |
AAH20026
AAK01427
BAB27973
BAC41008
BAE21183
BAE36815
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