Version 5.4
Mus musculus Protein: F2
Summary
InnateDB Protein IDBP-258350.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol F2
Protein Name coagulation factor II
Synonyms Cf-2; Cf2; FII; thrombin;
Species Mus musculus
Ensembl Protein ENSMUSP00000106967
InnateDB Gene IDBG-191373 (F2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006953 acute-phase response
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0010468 regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030307 positive regulation of cell growth
GO:0070493 thrombin receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:88380
InterPro IPR000001 Kringle
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003966 Prothrombin/thrombin
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR018992 Thrombin light chain
PFAM PF00051
PF00594
PF00089
PF09396
PRINTS PR00001
PR00722
PR01505
PIRSF PIRSF001149
SMART SM00130
SM00069
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H7BX99
UniProt Splice Variant
Entrez Gene 14061
UniGene Mm.89048
RefSeq
MGI ID
MGI Symbol F2
OMIM
CCDS
HPRD
IMGT
EMBL AL691489
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca