Version 5.4
Mus musculus Gene: F2
Summary
InnateDB Gene IDBG-191373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2
Gene Name coagulation factor II
Synonyms Cf-2; Cf2; FII; thrombin
Species Mus musculus
Ensembl Gene ENSMUSG00000027249
Encoded Proteins
IDBP-191375
coagulation factor II
IDBP-258350
coagulation factor II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180210:
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91625320-91636414
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000028681 ENSMUSP00000028681
ENSMUST00000111335 ENSMUSP00000106967
ENSMUST00000153182
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0070053 thrombospondin receptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006508 proteolysis
GO:0006953 acute-phase response
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010468 regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030194 positive regulation of blood coagulation
GO:0030307 positive regulation of cell growth
GO:0032967 positive regulation of collagen biosynthetic process
GO:0042730 fibrinolysis
GO:0045861 negative regulation of proteolysis
GO:0048712 negative regulation of astrocyte differentiation
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 cytosolic calcium ion homeostasis
GO:0070493 thrombin receptor signaling pathway
GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000180210
View Gene Order
ENSBTAG00000007148
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_245393
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_239392
Intrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_235159
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_254191
Gamma-carboxylation of protein precursors pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_255710
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_259461
Common Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_326
Intrinsic Pathway pathway
REACT_1439
Common Pathway pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_1050
Gamma-carboxylation of protein precursors pathway
REACT_1906
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_733
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_1132
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_14797
Signaling by GPCR pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_604
Hemostasis pathway
REACT_212120
Gamma-carboxylation of protein precursors pathway
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_216886
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_220023
Common Pathway pathway
REACT_205369
Signaling by GPCR pathway
REACT_206584
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_206454
Intrinsic Pathway pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_217199
Platelet Aggregation (Plug Formation) pathway
REACT_214353
Signal Transduction pathway
REACT_216819
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_215912
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_201970
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_206715
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_217138
Formation of Fibrin Clot (Clotting Cascade) pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
thrombin_pathway
Thrombin/protease-activated receptor (PAR) pathway
syndecan_4_pathway
Syndecan-4-mediated signaling events
thrombin_par4_pathway
PAR4-mediated thrombin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.89048
RefSeq NM_010168
OMIM
CCDS CCDS16434
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca