InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apoa2

Summary

InnateDB Protein

IDBP-258378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoa2

Protein Name

apolipoprotein A-II

Synonyms

Alp-2; Apoa-2; ApoA-II; ApoAII; Hdl-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106953

InnateDB Gene

IDBG-204212 (Apoa2)

Protein Structure

UniProt Annotation

Function

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Subcellular Localization

Secreted.

Disease Associations

Note=Defects in Apoa2 are the cause of senescence accelerated mouse (SAM), the senile amyloid is a mutated apolipoprotein A-II.

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008035	high-density lipoprotein particle binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity
GO:0031210	phosphatidylcholine binding
GO:0034190	apolipoprotein receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0055102	lipase inhibitor activity
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0002526	acute inflammatory response
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0006457	protein folding
GO:0006631	fatty acid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0009395	phospholipid catabolic process
GO:0009749	response to glucose
GO:0010873	positive regulation of cholesterol esterification
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0015759	beta-glucoside transport
GO:0018158	protein oxidation
GO:0018206	peptidyl-methionine modification
GO:0030300	regulation of intestinal cholesterol absorption
GO:0031100	organ regeneration
GO:0031647	regulation of protein stability
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034380	high-density lipoprotein particle assembly
GO:0034384	high-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0043085	positive regulation of catalytic activity
GO:0043627	response to estrogen
GO:0043691	reverse cholesterol transport
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0046340	diacylglycerol catabolic process
GO:0050995	negative regulation of lipid catabolic process
GO:0050996	positive regulation of lipid catabolic process
GO:0051384	response to glucocorticoid
GO:0060192	negative regulation of lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0060695	negative regulation of cholesterol transporter activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0034361	very-low-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron