Version 5.4
Mus musculus Gene: Apoa2
Summary
InnateDB Gene IDBG-204212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apoa2
Gene Name apolipoprotein A-II
Synonyms Alp-2; Apoa-2; ApoA-II; ApoAII; Hdl-1
Species Mus musculus
Ensembl Gene ENSMUSG00000005681
Encoded Proteins
IDBP-204214
apolipoprotein A-II
IDBP-258378
apolipoprotein A-II
IDBP-258380
apolipoprotein A-II
IDBP-258382
apolipoprotein A-II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158874:
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171225054-171226379
Strand Forward strand
Band H3
Transcripts
ENSMUST00000005824 ENSMUSP00000005824
ENSMUST00000111321 ENSMUSP00000106953
ENSMUST00000111320 ENSMUSP00000106952
ENSMUST00000111319 ENSMUSP00000106951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
GO:0031210 phosphatidylcholine binding
GO:0034190 apolipoprotein receptor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0055102 lipase inhibitor activity
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653 high-density lipoprotein particle receptor binding
Biological Process
GO:0002526 acute inflammatory response
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0006457 protein folding
GO:0006631 fatty acid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0009395 phospholipid catabolic process
GO:0009749 response to glucose
GO:0010873 positive regulation of cholesterol esterification
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0015759 beta-glucoside transport
GO:0018158 protein oxidation
GO:0018206 peptidyl-methionine modification
GO:0030300 regulation of intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0031100 organ regeneration
GO:0031647 regulation of protein stability
GO:0032375 negative regulation of cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034370 triglyceride-rich lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034384 high-density lipoprotein particle clearance
GO:0042157 lipoprotein metabolic process
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0043085 positive regulation of catalytic activity
GO:0043627 response to estrogen
GO:0043691 reverse cholesterol transport
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0046340 diacylglycerol catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0051384 response to glucocorticoid
GO:0060192 negative regulation of lipase activity
GO:0060621 negative regulation of cholesterol import
GO:0060695 negative regulation of cholesterol transporter activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158874
View Gene Order
ENSBTAG00000009212
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_216017
Chylomicron-mediated lipid transport pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188260
Visual phototransduction pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
KEGG
mmu03320
PPAR signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_6841
Chylomicron-mediated lipid transport pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_206940
Chylomicron-mediated lipid transport pathway
REACT_204227
Retinoid metabolism and transport pathway
REACT_212432
Lipoprotein metabolism pathway
REACT_223698
Visual phototransduction pathway
REACT_214353
Signal Transduction pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_207087
Disease pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P09813
TrEMBL
UniProt Splice Variant
Entrez Gene 11807
UniGene
RefSeq NM_013474 XM_006496625
OMIM
CCDS CCDS35773
HPRD
IMGT
MGI ID MGI:88050
MGI Symbol Apoa2
EMBL AC084821 AK145823 BC031786 CH466520 M32360 M79361 M79362 X04119 X62772
GenPept AAA37248 AAA37249 AAA37250 AAH31786 BAE26675 CAA27731 CAA44616 EDL39118 EDL39119 EDL39120 EDL39121
RNA Seq Atlas 11807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca