InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp21

Summary

InnateDB Protein

IDBP-258417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp21

Protein Name

ubiquitin specific peptidase 21

Synonyms

ESTM28; Usp16; Usp23; W53272;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106938

InnateDB Gene

IDBG-204358 (Usp21)

Protein Structure

UniProt Annotation

Function

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin- 1 conjugates. {ECO:0000269PubMed:18172164}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0008234	cysteine-type peptidase activity
GO:0019784	NEDD8-specific protease activity
GO:0036459	ubiquitinyl hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016578	histone deubiquitination
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1353665

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZL6

PhosphoSite

PhosphoSite-Q9QZL6

TrEMBL

UniProt Splice Variant

Entrez Gene

30941

UniGene

Mm.421891

RefSeq

MGI ID

MGI Symbol

Usp21

OMIM

CCDS

HPRD

IMGT

EMBL

AF177759 AK011148 BC021903

GenPept

AAD54322 AAH21903 BAB27431