Version 5.4
Mus musculus Gene: Usp21
Summary
InnateDB Gene IDBG-204358.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp21
Gene Name ubiquitin specific peptidase 21
Synonyms ESTM28; Usp16; Usp23; W53272
Species Mus musculus
Ensembl Gene ENSMUSG00000053483
Encoded Proteins
IDBP-204360
ubiquitin specific peptidase 21
IDBP-258417
ubiquitin specific peptidase 21
IDBP-258419
ubiquitin specific peptidase 21
IDBP-533526
ubiquitin specific peptidase 21
IDBP-622122
ubiquitin specific peptidase 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143258:
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171281945-171287991
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000065941 ENSMUSP00000064002
ENSMUST00000111306 ENSMUSP00000106938
ENSMUST00000111305 ENSMUSP00000106936
ENSMUST00000149187 ENSMUSP00000120161
ENSMUST00000144393
ENSMUST00000142656
ENSMUST00000126729
ENSMUST00000126557
ENSMUST00000147176
ENSMUST00000127101
ENSMUST00000153164
ENSMUST00000174720 ENSMUSP00000133362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0008234 cysteine-type peptidase activity
GO:0019784 NEDD8-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016578 histone deubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143258
View Gene Order
ENSBTAG00000021893
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.27510 Mm.421891
RefSeq NM_013919
OMIM
CCDS CCDS35774
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca