InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dedd

Summary

InnateDB Protein

IDBP-258427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dedd

Protein Name

death effector domain-containing

Synonyms

CASP8IP1; Dedpro1; DEFT; FLDED1; KE05;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106930

InnateDB Gene

IDBG-204417 (Dedd)

Protein Structure

UniProt Annotation

Function

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro. {ECO:0000250, ECO:0000269PubMed:9774341}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95- mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9774341}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0042177	negative regulation of protein catabolic process
GO:0042981	regulation of apoptotic process
GO:0046697	decidualization
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter