InnateDB Protein
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IDBP-258445.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nit1
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Protein Name
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nitrilase 1
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Synonyms
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AI255805; ESTM30; W57327;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106926
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InnateDB Gene
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IDBG-204444 (Nit1)
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Protein Structure
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Function |
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T- cells. Has apparently no omega-amidase activity such as NIT2. {ECO:0000269PubMed:16864578, ECO:0000269PubMed:19395373, ECO:0000269PubMed:19479888, ECO:0000269PubMed:19595734, ECO:0000269PubMed:19596042}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19479888}. Mitochondrion {ECO:0000269PubMed:19479888}.
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Disease Associations |
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Tissue Specificity |
Expressed in most tissues with higher expression in adult liver and kidney as well as in fetal adrenal gland and skeletal muscle. {ECO:0000269PubMed:16864578, ECO:0000269PubMed:9671749}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016810
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1350916
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InterPro |
IPR003010
Carbon-nitrogen hydrolase
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PFAM |
PF00795
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VDK1
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PhosphoSite |
PhosphoSite-Q8VDK1
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TrEMBL |
D3Z3I3
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UniProt Splice Variant |
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Entrez Gene |
27045
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UniGene |
Mm.472271
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RefSeq |
NP_036179
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MGI ID |
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MGI Symbol |
Nit1
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OMIM |
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CCDS |
CCDS35775
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HPRD |
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IMGT |
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EMBL |
AC084821
AC087229
AF069985
AF069988
BC021634
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GenPept |
AAC40184
AAC40185
AAH21634
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