InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncf1

Summary

InnateDB Protein

IDBP-258476.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncf1

Protein Name

neutrophil cytosolic factor 1

Synonyms

Ncf-1; NCF-47K; NOXO2; p47-phox; p47; p47phox;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106906

InnateDB Gene

IDBG-202592 (Ncf1)

Protein Structure

UniProt Annotation

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000269PubMed:9490028}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0017124	SH3 domain binding
GO:0035091	phosphatidylinositol binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0001878	response to yeast
GO:0001909	leukocyte mediated cytotoxicity
GO:0002679	respiratory burst involved in defense response
GO:0006612	protein targeting to membrane
GO:0006691	leukotriene metabolic process
GO:0006742	NADP catabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0008283	cell proliferation
GO:0009617	response to bacterium
GO:0042554	superoxide anion generation
GO:0042742	defense response to bacterium
GO:0045730	respiratory burst
GO:0045986	negative regulation of smooth muscle contraction
GO:0050665	hydrogen peroxide biosynthetic process
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0055114	oxidation-reduction process
GO:0070946	neutrophil mediated killing of gram-positive bacterium
GO:0070947	neutrophil mediated killing of fungus

Cellular Component

GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0019898	extrinsic component of membrane
GO:0030425	dendrite
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:97283

InterPro

IPR001452 SH3 domain
IPR001655 Neutrophil cytosol factor 1
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
IPR015039 NADPH oxidase subunit p47Phox, C-terminal

PFAM

PF00018
PF14604
PF00787
PF07653
PF08944

PRINTS

PR00452
PR00498

PIRSF

SMART

SM00326
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt