Version 5.4
Mus musculus Protein: Setdb2
Summary
InnateDB Protein IDBP-258533.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setdb2
Protein Name SET domain, bifurcated 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106884
InnateDB Gene IDBG-169918 (Setdb2)
Protein Structure
UniProt Annotation
Function Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 0
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046974 histone methyltransferase activity (H3-K9 specific)
Biological Process
GO:0001947 heart looping
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051567 histone H3-K9 methylation
GO:0070986 left/right axis specification
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID MGI:2685139
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C267
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 628705
UniGene Mm.205022
RefSeq
MGI ID
MGI Symbol Setdb2
OMIM
CCDS
HPRD
IMGT
EMBL AC114007 AK089197
GenPept BAC40789

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca