InnateDB Protein
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IDBP-258537.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pex19
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Protein Name
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peroxisomal biogenesis factor 19
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Synonyms
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Pxf;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106883
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InnateDB Gene
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IDBG-205149 (Pex19)
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Protein Structure
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Function |
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Mainly cytoplasmic, some fraction membrane- associated to the outer surface of peroxisomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
35 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1334458
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InterPro |
IPR006708
Pex19 protein
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PFAM |
PF04614
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VCI5
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PhosphoSite |
PhosphoSite-Q8VCI5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19298
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UniGene |
Mm.488816
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RefSeq |
NP_001152997
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MGI ID |
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MGI Symbol |
Pex19
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OMIM |
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CCDS |
CCDS48445
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HPRD |
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IMGT |
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EMBL |
AK012785
AK028449
AK029368
BC012517
BC019767
CT010305
Y09046
Y09047
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GenPept |
AAH12517
AAH19767
BAB28468
BAC25957
BAC26421
CAA70255
CAA70256
CAJ18513
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