InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cadm3

Summary

InnateDB Protein

IDBP-258589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cadm3

Protein Name

cell adhesion molecule 3

Synonyms

BIgR; Igsf4b; Necl-1; Necl1; SynCAM3; Tsll1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106851

InnateDB Gene

IDBG-205840 (Cadm3)

Protein Structure

UniProt Annotation

Function

Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. {ECO:0000269PubMed:15741237, ECO:0000269PubMed:15893517}.

Subcellular Localization

Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at the cell-cell attached sites of the plasma membrane.

Disease Associations

Tissue Specificity

Mainly expressed in brain, in neuronal cell bodies of cerebellum, cortex, hippocampus, hypothalamus and spinal cord. In spinal cord predominantly expressed in motor neurons. Expressed in axons, presynaptic nerve terminals, glia cell processes. {ECO:0000269PubMed:14659875, ECO:0000269PubMed:15741237, ECO:0000269PubMed:15893517}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0008104	protein localization

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2137858

InterPro

IPR003585 Neurexin/syndecan/glycophorin C
IPR003597 Immunoglobulin C1-set
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00294
SM00407
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99N28