InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc1a2

Summary

InnateDB Protein

IDBP-258604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc1a2

Protein Name

solute carrier family 1 (glial high affinity glutamate transporter), member 2

Synonyms

1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; GLT-1; GLT1; MGLT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106843

InnateDB Gene

IDBG-193462 (Slc1a2)

Protein Structure

UniProt Annotation

Function

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform GLT1 is expressed in the brain. Isoforms GLT-1A and GLT-1B are expressed in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0015501	glutamate:sodium symporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006835	dicarboxylic acid transport
GO:0007399	nervous system development
GO:0007632	visual behavior
GO:0009416	response to light stimulus
GO:0009611	response to wounding
GO:0010259	multicellular organismal aging
GO:0015813	L-glutamate transport
GO:0021537	telencephalon development
GO:0030534	adult behavior
GO:0031668	cellular response to extracellular stimulus
GO:0035264	multicellular organism growth
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0046326	positive regulation of glucose import
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import