Version 5.4
Mus musculus Protein: Wdr35
Summary
InnateDB Protein IDBP-258809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr35
Protein Name WD repeat domain 35
Synonyms 4930459M12Rik; 4931430C06; mKIAA1336;
Species Mus musculus
Ensembl Protein ENSMUSP00000106742
InnateDB Gene IDBG-128551 (Wdr35)
Protein Structure
UniProt Annotation
Function May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. {ECO:0000250, ECO:0000269PubMed:21473986}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:21473986}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:21473986}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:21473986}. Note=Immunofluorescence studies in IMCD3 cells show that Wdr35 accumulates at and around centrosomes and basal bodies of serum-starved cells, with fainter punctate staining along the cilia axoneme.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0042384 cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID MGI:1921932
InterPro IPR001680 WD40 repeat
IPR016024 Armadillo-type fold
IPR017233 WD repeat protein 35
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF PIRSF037536
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BND3
PhosphoSite PhosphoSite-Q8BND3
TrEMBL Q9CUL7
UniProt Splice Variant
Entrez Gene 74682
UniGene Mm.87389
RefSeq NP_001152999
MGI ID
MGI Symbol Wdr35
OMIM
CCDS CCDS49027
HPRD
IMGT
EMBL AC110376 AK015490 AK029896 AK083971 BC056925
GenPept AAH56925 BAB29866 BAC26663 BAC39081

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca