Version 5.4
Mus musculus Gene: Wdr35
Summary
InnateDB Gene IDBG-128551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr35
Gene Name WD repeat domain 35
Synonyms 4930459M12Rik; 4931430C06; mKIAA1336
Species Mus musculus
Ensembl Gene ENSMUSG00000066643
Encoded Proteins
IDBP-128553
WD repeat domain 35
IDBP-258809
WD repeat domain 35
IDBP-539583
WD repeat domain 35
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118965:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8973892-9028847
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000085745 ENSMUSP00000082895
ENSMUST00000111113 ENSMUSP00000106742
ENSMUST00000159126
ENSMUST00000160329 ENSMUSP00000124285
ENSMUST00000161019
ENSMUST00000160873
ENSMUST00000159735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0035721 intraciliary retrograde transport
GO:0042384 cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000118965
View Gene Order
Pathways
NETPATH
REACTOME
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.482934 Mm.87389
RefSeq NM_001159527 NM_172470
OMIM
CCDS CCDS25807 CCDS49027
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca